AVAILABLE TREATMENTS FOR TYPE 2 DIABETES: A REVIEW

Treatments for Type 2 Diabetes

G lucagon-like peptide-1 (GLP-1) is produced by the proglucagon gene in L-cells of the small intestine in response to nutrients.1 It is an incretin – a gut hormone – that is responsible for the greater insulin response to oral versus IV glucose.2 Its major mechanism of action occurs through stimulation of glucose-dependent insulin release from the pancreatic islets. In addition to its insulinot...

Cost effectiveness of type 2 diabetes screening: A systematic review

Background: Although studies reported diabetes mellitus screening cost effective, the mass screening for type2 diabetes remains controversial. In this study we reviewed the recently evidence about the cost effectiveness of mass screening systematically.   Methods: We reviewed the MEDLINE, Scopus, Web of Science (WOS), and Cochrane library databases by MeSH terms to identify relevan...

Genetics of Type 2 Diabetes- A Review Article

Objective: Type 2 diabetes (T2D) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. Linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. However, they were largely unsuccessful while applying to the more common forms of disease. By designing Genome Wi...

Novel treatments for type 2 diabetes.

Treatments for Type 2 Diabetes; a Focus on DPP4 Inhibitors

New treatments for diabetes are always exciting in the beginning but as experience grows their position in management becomes less certain. This review focuses on DPP4 inhibitors and their place in management of type 2 diabetes. Although hypoglycaemia is rarely an issue, the effectiveness in reduction in blood sugar is greatest at the higher blood sugar levels, hence much of the value of using ...